Mephentermine is structurally similar to methamphetamine and is banned by world anti-doping agency due to its abuse as performance enhancing drug. Reports of Mephentermine abuse and dependence are emerging recently in competitive sports which might lead to psychosis and harmful effects. Here we describe a case of Mephentermine misuse in a body builder prescribed by his trainer in gym which led to psychosis. The client showed improvement with parenteral haloperidol and promethazine combination followed by oral haloperidol and motivation enhancement therapy. Our case report highlights the need of effective treatment options and spreading awareness regarding harmful effects among athletes and also need of the vigilance on drugs availability in gym which further emphasizes to concentrate on this area by the policy makers.